ՀԱՅԱՍՏԱՆԻ ԿԵՆՍԱԲԱՆԱԿԱՆ ՀԱՆԴԵՍ =Biological Journal of Armenia

Gender-related differences of physical parameters of rat erythrocyte membranes

Sahakyan, G. V. and Artsruni, G. G. and Poghosyan, G. A. (2014) Gender-related differences of physical parameters of rat erythrocyte membranes. Հայաստանի կենսաբանական հանդես Biological Journal of Armenia Биологический журнал Армении, 66 (1). pp. 72-77. ISSN 0366-5119

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Abstract

The gender-related differences of some biophysical parameters of rat erythrocyte ghosts are investigated by spectrophotometric method using the fluorescent probes ANS and pyrene. Data obtained show that the ghosts of male rat erythrocytes are more negative charged than females’ and the straight of the bounding of peripheral proteins with lipid bilayer for female erythrocytes is less then for males’. The viscosity of female erythrocyte ghosts is more, but the compactness of the packing of phospholipids in lipid bilayer is less then in males’, while the microviscosity of male erythrocyte ghosts is more then females’. These results testified that, in all probability, there are structural and functional gender-related differences in membrane level and these sex-related structural specificities of cell membranes can underlie the gender-related differences in pharmacokinetics and pharmacodinamics.

Item Type:Article
Additional Information:Половые различия физических параметров эритроцитарных мембран крыс / Г. В. Саакян, Г. Г. Арцруни, Г. А. Погосян. Առնետների էրիթրոցիտային թաղանթների ֆիզիկական չափանիշների սեռ-կախյալ տարբերությունները / Գ. Վ. Սահակյան, Գ. Գ. Արծրունի, Գ. Ա. Պողոսյան։
Uncontrolled Keywords:Gender-related differences – erythrocyte ghost – membrane structure
Subjects:Biology > Pharmacology
ID Code:11095
Deposited By:Ruzan Tumanyan
Deposited On:07 May 2014 11:24
Last Modified:08 May 2014 11:24

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