ՀԱՅԱՍՏԱՆԻ ԿԵՆՍԱԲԱՆԱԿԱՆ ՀԱՆԴԵՍ =Biological Journal of Armenia

The influence of NG-hydroxy-L-arginine on the activity of the urea cycle enzymes

Javrushyan, H. G. (2014) The influence of NG-hydroxy-L-arginine on the activity of the urea cycle enzymes. Հայաստանի կենսաբանական հանդես Biological Journal of Armenia Биологический журнал Армении, 66 (1). pp. 113-117. ISSN 0366-5119

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Abstract

Between the relationship of NOS (NO-synthase) and arginase in complicated and peculiar metabolic pathway of L-arginine there are many undiscovered points up till now. The aim of our study was to investigate the influence of NG-hydroxy-L-arginine (NOHA) on the activity of urea cycle enzymes in vitro. Studies have shown that NOHA decreases the activity of all the urea cycle enzymes in liver, except ureotelic arginase, and increases the activity of argininosuccinate synthase and argininosuccinatelyase in brain and kidney. Our results show that the influence of NOHA on various organs in a different way is a new revelation in the pathway of L-arginine. We show that NOHA performs an important role in the metabolism of urea cycle metabolites (ornithine, citrulline and arginine) in different tissues.

Item Type:Article
Additional Information:NG-հիդրօքսի-L-արգինինի ազդեցությունը օրնիթինային ցիկլի ֆերմենտների ակտիվության վրա / Հ. Գ. Ջավրուշյան։ Влияниe NG- гидрокси - L- аргинина на активность ферментов цикла мочевины / А. Г. Джаврушян.
Uncontrolled Keywords:Urea cycle – NG-hydroxy-L-arginine – nitric oxide – arginase
Subjects:Biology > Biochemistry
ID Code:11103
Deposited By:Ruzan Tumanyan
Deposited On:07 May 2014 12:07
Last Modified:08 May 2014 11:32

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